Milla and Evelina are sixty years old and no longer keep in touch. In their twenties, they were best friends, but the choices they made drove them apart, leading them to live completely opposite lives. Milla’s existence is bourgeois, conventional, and seemingly perfect, while Evelina’s is bohemian, creative, and chaotic. However, the sudden death of Adriana unexpectedly brings them back together.

Adriana, the third member of their once-indissoluble university trio, dedicated her life to saving whales. At the beginning of the series, she tragically dies at sea in what appears to be a “simple” accident. Just before the incident, she had tried calling both Milla and Evelina, but neither of them had answered. The two women are shaken and guilt-ridden. When they come across social media posts questioning the plausibility of the accident, they start to wonder: was Adriana actually murdered? It’s a suspicion with no concrete evidence, yet it is enough to push them into investigating Adriana’s life, uncovering secrets and hidden truths. As they piece together their friend’s story, they are also forced to take a hard look at their own lives, facing the major upheavals ahead.

Milla discovers that her husband, Walter—whom she has devoted thirty years of her life to, sacrificing her professional ambitions—has been unfaithful. She leaves him, throws him out of the house, and, once she has recovered from her grief, walks into the family business to claim the presidency that has, until then, been hers in name only. Evelina, on the other hand, clashes with Riccardo Villa, an economist appointed by the Ministry to modernize and stabilize the shaky management of the Academy of Fine Arts, where Evelina teaches. To her, Riccardo is the kind of man who knows nothing about art but everything about money, social media, and other matters she couldn’t care less about. In short, she immediately dislikes him. But as the saying goes, “those who despise, buy,” and inevitably, their relationship will extend beyond the professional realm.

At sixty, the two friends find themselves facing unexpected challenges and emotions that reveal one of life’s most underrated truths: one can still be surprised by oneself and grow—even, or especially, later in life. With their resilience and rekindled friendship, Evelina and Milla navigate their most difficult moments, find a new balance for themselves and their families, and ultimately uncover the truth about Adriana’s death. From this, they learn a valuable lesson: life is beautiful at twenty, at sixty, and always—it should never be wasted.

As Milla and Evelina reconnect, so do their children, Flaminia and Emanuele. They had a brief romance in their youth and now meet again at Adriana’s funeral. Emanuele, who is separated and focused on raising his daughter Zina, has put his romantic and sexual life on hold. However, seeing Flaminia reignites the attraction he once felt for her. Flaminia, on the other hand, has become a workaholic incapable of maintaining stable relationships. For her, men are just casual flings, and she convinces herself that she and Emanuele should remain just friends.

As they support each other through difficult times with their respective mothers, Flaminia comes to realize that she does have feelings for Emanuele. The problem? By the time she figures it out, she has practically pushed him into the arms of her friend, Susanna.